Hypercalcaemia associated with chronic lymphocytic leukaemia in a Giant Schnauzer. |
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| Authors: | M Kleiter R Hirt G Kirtz M J Day |
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| Institution: | I. Medical Clinic for Small Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria. |
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| Abstract: | A 7-year-old male Giant Schnauzer was referred with a history of severe vomiting, lethargy, weight loss, polydipsia and polyuria. Detailed investigations revealed leucocytosis with a marked lymphocytosis, mild non-regenerative anaemia, thrombocytopenia, hypercalcaemia and azotaemia. Circulating lymphocytes were small and well-differentiated, and the same lymphoid population was present in bone marrow. Chronic lymphocyctic leukaemia with associated paraneoplastic hypercalcaemia was diagnosed. Immunohistochemical staining of a bone marrow biopsy revealed a neoplastic B-cell line expressing CD79. The dog responded to therapy with prednisolone and chlorambucil for a period of 8 months. |
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| Keywords: | Dog chronic lymphocytic leukaemia paraneoplastic syndrome hypercalcaemia |
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