| 口蹄疫病毒前导蛋白酶抑制宿主先天性免疫应答的机制 |
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| 引用本文： | 李夏莹,许文涛,汪其怀.口蹄疫病毒前导蛋白酶抑制宿主先天性免疫应答的机制[J].中国畜牧兽医,2015,42(4):1028-1031. |
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| 作者姓名： | 李夏莹 许文涛 汪其怀 |
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| 作者单位： | 1. 农业部科技发展中心, 北京 100122;2. 中国农业大学食品科学与营养工程学院, 北京 100083;3. 农业部转基因生物食用安全监督检验测试中心(北京), 北京 100083 |
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| 基金项目： | 转基因生物新品种培育重大专项(2014ZX0801103B);食品质量与安全北京实验室 |
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| 摘 要： | 口蹄疫是由口蹄疫病毒(foot-and-mouth disease virus,FMDV)引起的一种急性、热性、高度接触传染性动物疫病。口蹄疫病毒有多种机制对抗宿主的先天性免疫应答,在这个过程中病毒的前导蛋白酶(Lpro)发挥了关键作用。Lpro可切断宿主细胞帽子依赖性的蛋白翻译,抑制干扰素蛋白的合成;Lpro通过破坏核转录因子-κB(NF-κB)的完整性或减少干扰素调节因子3/7(IRF3/7)的表达,从而抑制IFN mRNA的产生;Lpro还会参与维甲酸诱导基因Ⅰ(RIG-Ⅰ)、TANK结合激酶1(TBK1)、TNF受体相关因子3(TRAF3)和TRAF6的去泛素化,从而影响Ⅰ型干扰素信号通路的活化。
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| 关 键 词： | 口蹄疫病毒 前导蛋白酶 Ⅰ型干扰素 先天性免疫应答 |
| 收稿时间： | 2014-10-31 |
Mechanism of Foot-and-mouth Disease Virus Leader Protease to Inhibit Host Innate Immune Response |
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| LI Xia-ying,XU Wen-tao,WANG Qi-huai.Mechanism of Foot-and-mouth Disease Virus Leader Protease to Inhibit Host Innate Immune Response[J].China Animal Husbandry & Veterinary Medicine,2015,42(4):1028-1031. |
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| Authors: | LI Xia-ying XU Wen-tao WANG Qi-huai |
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| Institution: | 1. Development Center of Science and Technology, Ministry of Agriculture, Beijing 100122, China;2. College of Food Science and Nutrition Engineering, China Agricultural University, Beijing 100083, China;3. Supervision, Inspection & Testing Center of Genetically Modified Food Safety, Ministry of Agriculture, Beijing 100083, China |
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| Abstract: | Foot-and-mouth disease (FMD) is an acute, febrile, highly contagious animal disease caused by foot-and-mouth disease virus (FMDV). FMDV has a variety of mechanisms resisting host innate immune response, leader protease (Lpro) has played a key role in the process. Lpro can cut off the host cell cap-dependent translation, inhibiting the synthesis of interferon. Lpro through destroying the integrity of NF-κB or reducing the expression of IRF3/7, inhibits the production of interferons mRNA. Besides, Lpro can take part in the deubiquitination of reninoic-acid-inducible gene Ⅰ (RIG-Ⅰ), TANK binding kinase 1 (TBK1), TNF receptor-associate factor 3 (TRAF3) and TRAF6, thus affecting the activation of type Ⅰ interferon signaling pathway. |
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| Keywords: | FMDV leader protease typeⅠinterferon innate immune response |
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