Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta |
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| Authors: | Henderson N G Stear M J |
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| Institution: | Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK. |
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| Abstract: | Infections of sheep with the gastrointestinal nematode Teladorsagia circumcincta are characterised by increased concentrations of IgA, eosinophilia and mastocytosis but the interactions between these immune responses are unclear. We investigated the kinetics of the parasite-specific IgA and eosinophil responses in controlled infections in lambs to determine if there were any associations with subsequent worm growth and survival. IgA and eosinophil responses had very similar kinetics and variation in both responses accounted for more of the variation in adult worm length than either trait alone suggesting that IgA and eosinophils interact in regulating the growth of T. circumcincta. Curiously, those animals with higher peak eosinophil responses had longer worms at slaughter emphasising the intriguing complexity of the immune responses to these parasitic infections. |
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