| 氨苄青霉素在鸡体内代谢动力学的研究 |
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| 引用本文： | 柳仲华,张福华.氨苄青霉素在鸡体内代谢动力学的研究[J].四川农业大学学报,1990,8(1):32-36. |
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| 作者姓名： | 柳仲华 张福华 |
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| 作者单位： | 四川农业大学兽医学系，四川农业大学兽医学系 |
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| 摘 要： | 雅安本地鸡11只,一次肌肉注射氨苄青霉素20mg/2g,血药浓度用荧光分光光度法测定,激发波/发射波波长为360/430mu。用MCPKP程序在IBM机上处理。动力学参数:其中八只鸡的半衰期为0.98小时,峰时为0.33小时。峰值为4.5ug/ml,血液中有效浓度维持时间为5.44小时;其中三只鸡的吸收相半衰期为0.02小时,分布相半衰期为0.34小时,消除相半衰期为2.51小时,峰时为0.12小时,峰值为10.93ug/ml,血液中有效浓度维持时间为10.54小时。
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| 关 键 词： | 药物动力学(47UA) 生物鉴定(45AA) 鸡(49ME) 氨苄青霉素 药物血液浓度 |
PHARMACOKINETINCS OF AMPICILLIN IN HENS |
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| Liu Zhonghua Zhang Fuhua.PHARMACOKINETINCS OF AMPICILLIN IN HENS[J].Journal of Sichuan Agricultural University,1990,8(1):32-36. |
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| Authors: | Liu Zhonghua Zhang Fuhua |
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| Abstract: | Pharmacokinetics of ampicillin for injections intramuscular were studied in healthy adult hens. A single dose(20mg/kg) of the drug was administered. Blood samples were collected at 0,.008, 0.17, 0.25, 0.5, 0.75, 1, 2, 3, 4, and 6 hours. The samples were determined by fluorometric method. The data were in accordance with one-compartment open model or two-compartment open model with first order absorption. The main kinetic parameters of ampicillin were determined, |
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| Keywords: | PHARMACOKINETICS BIOASSAY DOMES TICFOWL FREE WORDS: AMPICILLIN DRUG BLOOD CONCENTRATION |
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