| 茶多酚对活性氧引起的鸡胚睾丸细胞氧化损伤的保护作用 |
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| 引用本文： | 王新新,曾卫东,米玉玲,张才乔.茶多酚对活性氧引起的鸡胚睾丸细胞氧化损伤的保护作用[J].中国畜牧杂志,2008,44(19). |
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| 作者姓名： | 王新新 曾卫东 米玉玲 张才乔 |
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| 作者单位： | 浙江大学动物科学学院,浙江杭州,310029 |
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| 基金项目： | 教育部跨世纪优秀人才培养计划，浙江省自然科学基金 |
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| 摘 要： | 利用精原细胞-体细胞共培养模型研究茶多酚对鸡胚睾丸细胞氧化损伤的缓解作用。结果表明:由次黄嘌呤-黄嘌呤氧化酶体系产生的活性氧可引起脂质过氧化产物丙二醛(MDA)的生成量增加、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性降低,而添加0.1μg/mL的茶多酚能降低MDA的生成量、使SOD和GSH-Px的活性恢复到对照组水平。这些结果说明,茶多酚通过抗氧化作用对活性氧引起的鸡胚睾丸细胞的氧化损伤具有保护作用。
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| 关 键 词： | 茶多酚 精原细胞 氧化损伤 鸡 |
Protective Effects of Tea Polyphenols on Oxidative Damage Induced by Reactive Oxygen Species in Testicular Cells of Embryonic Chickens |
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| WANG Xin-xin,ZENG Wei-dong,MI Yu-ling,ZHANG Cai-qiao.Protective Effects of Tea Polyphenols on Oxidative Damage Induced by Reactive Oxygen Species in Testicular Cells of Embryonic Chickens[J].Chinese Journal of Animal Science,2008,44(19). |
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| Authors: | WANG Xin-xin ZENG Wei-dong MI Yu-ling ZHANG Cai-qiao |
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| Abstract: | The attenuating effect of tea polyphenols on reactive oxygen species-induced oxidative toxicity was evaluated with an embryonic chicken spermatogonial-somatic cell co-culture model.Results showed that exposure to hypoxanthine/xanthine oxidase induced an elevation in MDA,while a decrease in SOD activity and GSH-Px activity.However,simultaneous supplementation with tea polyphenols(0.1 μg/mL) decreased the levels of MDA to quench the free radicals,increased SOD activity and GSH-Px activity to restore the intracellular antioxidant defense system.Consequently,tea polyphenols may attenuate the negative effects of the reactive oxygen species to restore the antioxidant system in testicular cells. |
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| Keywords: | tea polyphenols spermatogonial cells oxidative damage chicken |
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