| SAMP8小鼠衰老海马complexin含量呈环路特异性下降 |
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| 引用本文： | 黄玲,杨启纲,卞文婧,陈勇平,陈贵海.SAMP8小鼠衰老海马complexin含量呈环路特异性下降[J].安徽农业大学学报,2012,39(3):345-347. |
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| 作者姓名： | 黄玲 杨启纲 卞文婧 陈勇平 陈贵海 |
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| 作者单位： | 安徽医科大学附属第一医院;安徽医科大学附属第一医院;安徽医科大学附属第一医院;安徽医科大学附属第一医院 |
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| 基金项目： | 国家自然科学基金项目(30872730);安徽省自然科学基金09020103001)资助 |
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| 摘 要： | 利用免疫组化技术检测年龄对SAMP8小鼠海马突触前蛋白complexin1/2表达的影响。结果显示,与4.5月龄相比,13月龄组齿状回多形细胞层和外分子层及CA1区放射层的complexin1/2相对含量均显著下降,8月龄组后两者也下降。此外13月龄组CA3透明层complexin1/2低于表达较8月龄组。这些结果提示在SAMP8鼠海马complexin1/2含量随年龄增加而呈现环路特异性下降。
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| 关 键 词： | 衰老 海马 complexin 免疫组化 小鼠 |
Circuit-specifically hippocampal reduction of complexin during aging in SAMP8 mice |
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| HUANG Ling,YANG Qi-gang,BIAN Wen-jing,CHEN Yong-ping and CHEN Gui-hai.Circuit-specifically hippocampal reduction of complexin during aging in SAMP8 mice[J].Journal of Anhui Agricultural University,2012,39(3):345-347. |
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| Authors: | HUANG Ling YANG Qi-gang BIAN Wen-jing CHEN Yong-ping and CHEN Gui-hai |
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| Institution: | 1(1.Department of Neurology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022; 2.Department of Biomedical Engineering,Johns Hopkins University,Baltimore MD21212) |
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| Abstract: | Using immunohistochemistry method,the aging effects on the levels of complexin1/2 in drosal hippocampus in the SAMP8 mice was explored.The results showed that compared to the 4.5-month mice,the 13-month mice had significantly lower level of complexin1/2 in the polymorphic layer and outer molecular layer of dentate gyrus and the stratum radiatum of CA1 subfield,so had the 8-month-old mice in the outer molecular layer of dentate gyrus and the stratum radiatum of CA1 subfield.In addition,complexin1/2 relative amount of the 13-month-old mice was significant lower than that of the 8-month-old mice in CA3 stratum lucidum.These results suggested that the levels of complexin1/2 expression in hippocampus appeared a circuit-specific reduction during aging in SAMP8 mice. |
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| Keywords: | aging complexin hippocampus immunohistochemistry mouse |
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