| 恩诺沙星在杂交鲟体内的药物代谢动力学 |
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| 引用本文： | 郭娇娇,潘红艳,杨虎,廖鑫,宫智勇,李谷.恩诺沙星在杂交鲟体内的药物代谢动力学[J].大连水产学院学报,2011,26(4):362-366. |
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| 作者姓名： | 郭娇娇 潘红艳 杨虎 廖鑫 宫智勇 李谷 |
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| 作者单位： | 1. 武汉工业学院食品科学与工程学院,湖北武汉,430023
2. 中国水产科学研究院长江水产研究所,湖北荆州,434000 |
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| 基金项目： | 国家科技支撑计划项目，武汉工业学院校研究生创新基金资助项目 |
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| 摘 要： | 采用高效液相色谱法,研究在单次口灌给药途径下,恩诺沙星在杂交鲟（施氏鲟Acipenser schrenckii♂×达氏鳇Huso dauricus♀）体内的药代动力学。对杂交鲟单次口灌给药恩诺沙星10 mg/kg后,用3P97药代动力学分析软件对实验数据进行了分析。结果表明：恩诺沙星在杂交鲟血液、肌肉和肝脏中的药物时量曲线关系符合一级吸收的二室开放模型;该药在血液、肌肉和组织中的平均回收率分别为93.6%±1.14%、92.65%±1.5%、92.82%±1.39%,在杂交鲟不同组织中分布较广,其在血液、肌肉和肝脏的表观分布容积v/f分别为26.987、6.2298、2.1515 L/kg;恩诺沙星在杂交鲟体内消除较慢,在血液、肌肉和肝脏中的消除半衰期分别为290.139、114.9、901.835 h,总体清除率分别为0.2288、0.1047、0.02164 L/（kg.h）。鉴于恩诺沙星在杂交鲟体内消除较慢,建议养成阶段使用其它药物。
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| 关 键 词： | 杂交鲟 恩诺沙星 药代动力学 |
Pharmacokinetics of enrofloxacin in sturgeon Acipenser schrenckii |
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| GUO Jiao-jiao,PAN Hong-yan,YANG Hu,LIAO Xin,GONG Zhi-yong,LI Gu.Pharmacokinetics of enrofloxacin in sturgeon Acipenser schrenckii[J].Journal of Dalian Fisheries University,2011,26(4):362-366. |
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| Authors: | GUO Jiao-jiao PAN Hong-yan YANG Hu LIAO Xin GONG Zhi-yong LI Gu |
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| Institution: | 1. College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023 ,China; 2. Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Jingzhou 434000, China) |
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| Abstract: | The pharmacokinetics of enrofloxacin in the sturgeon Acipenser schrenckii administrated by oral gavage at a dos of 10 mg/kg was investigated using the HPLC and by pharmacokinetics software 3P97. The concentrations versus time in plasma, muscle and liver in the sturgeon were well described by a two-department open model with first-order absorption, with the average enrofloxacin recovery of 93.6% ±1.14% in plasma,92.65% ±1.5% in muscle, and 92.82% ±1.39% in liver. The enrofloxacin in the sturgeon had the ability to be widely distributed to diverse tissues. The apparent volume of distribution was found to be 26. 987 L/kg in the plasma, 6. 2298 L/kg in the muscle and 2. 1515 L/kg in the liver. The enrofloxacin elimination was found slowly, the elimination half-life （ T1/2β ） of 290. 139 h in the plasma, 114.9 h in the muscle and 901. 835 h in the liver, and the total body clearance （Ct/f（s）） of 0.2288 L/（kg · h） in the plasma, 0. 1047 L/（kg · h） in the muscle and O. 02164 L/（kg · h） in the liver. So we suggest that other antibacterial drugs be used to prevent and treat bacterial diseases in the process of sturgeon growth on. |
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| Keywords: | Acipenser schrenckii enrofloxacin pharmacokinetics |
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