| 1,8-辛二醇的新合成方法研究 |
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| 引用本文： | 孔令大,郑志兵.1,8-辛二醇的新合成方法研究[J].林产化学与工业,2011,31(1):105-108. |
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| 作者姓名： | 孔令大 郑志兵 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 摘 要： | 研究了一种简便的、易于工业化的制备1,8-辛二醇的新方法.以1,8-辛二腈为原料,先在硫酸催化下和甲醇反应高收率地得到辛二酸二甲酯,接着辛二酸二甲酯在硼氢化钠-甲醇-四氢呋喃体系中还原得到产物1,8-辛二醇,重点考察了还原剂硼氢化钠用量及反应时间对1,8-辛二醇收率的影响,得到了较佳的工艺条件:硼氢化钠与辛二酸二甲酯的...
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| 关 键 词： | 1 8-辛二醇 辛二酸二甲酯 硼氢化钠-甲醇-四氢呋喃体系 合成 |
New Synthesis Method of 1.8-Octanediol |
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| KONG Ling-da,ZHENG Zhi-bing.New Synthesis Method of 1.8-Octanediol[J].Chemistry & Industry of Forest Products,2011,31(1):105-108. |
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| Authors: | KONG Ling-da ZHENG Zhi-bing |
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| Institution: | KONG Ling-da,ZHENG Zhi-bing(Institute of Pharmacology and Toxicology,Academy of Miliary Medical Sciences,Beijing 100850,China) |
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| Abstract: | A convenient and industrializable new method of synthesizing 1,8-octanediol was studied.1,8-Octanedioic acid dimethyl ester was obtained at high yield,using hexamethylene dicyanide and methanol as raw material catalyzed by concentrated sulfuric acid,followed by the reduction of 1,8-octanedioic acid dimethyl ester via sodium borohydride in a NaBH4-methanol-tetrahydrofuran solvent system to obtain 1,8-octanediol.Effects of the amount of NaBH4 and reaction time on the overall yield of 1,8-octanediol were inves... |
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| Keywords: | 1 8-octanediol octanedioic acid dimethyl ester NaBH4-methanol-tetrahydrofuran system synthesis |
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