Baylis-Hillman adducts with molluscicidal activity against Biomphalaria glabrata |
| |
| Authors: | Vasconcellos Mário Laa Silva Tania Ms Camara Celso A Martins Rodrigo M Lacerda Kelly M Lopes Horacimone M Pereira Vera Lp de Souza Rodrigo Oma Crespo Lívia Tc |
| |
| Institution: | Departamento de Química, Universidade Federal da Paraíba, Campus I, Jo?o Pessoa, PB, Brazil. mlaav@quimica.ufpb.br |
| |
| Abstract: | The molluscicidal activities of ten Baylis-Hillman adducts against Biomphalaria glabrata (Say) snails, the intermediate host of schistosomiasis, have been determined. Nine of these compounds showed significant molluscicidal activity against B. glabrata, falling below the threshold of 100 microg ml(-1) set for potential molluscicidal activity by the World Health Organisation. Among these compounds, 3-hydroxy-2-methylene-3-(4-nitrophenyl)propanenitrile had the highest activity, with LC(50) = 6.64 microg ml(-1). |
| |
| Keywords: | schistosomiasis molluscicidal activity Biomphalaria glabrata Baylis–Hillman reaction |
| 本文献已被 PubMed 等数据库收录！ |
|
