Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44 |
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| Authors: | Chun-Shun Li Xiao-Ming Li Shu-Shan Gao Yan-Hua Lu Bin-Gui Wang |
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| Institution: | 1.Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China; E-Mails: (C.-S.L.); (X.-M.L.); (S.-S.G.) ;2.State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai 200237, China; E-Mail: |
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| Abstract: | Five new anthranilic acid derivatives, penipacids A–E (1–5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line. |
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| Keywords: | marine fungus sediment anthranilic acid Penicillium paneum cytotoxicity |
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