| 玉米赤霉烯酮对小鼠胸腺上皮细胞的毒性作用 |
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| 引用本文： | 梁梓森,许利娜,马勇江,邓衔柏,李英,范小龙,李玉谷,宁章勇.玉米赤霉烯酮对小鼠胸腺上皮细胞的毒性作用[J].中国兽医学报,2009,29(7). |
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| 作者姓名： | 梁梓森 许利娜 马勇江 邓衔柏 李英 范小龙 李玉谷 宁章勇 |
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| 作者单位： | 华南农业大学,兽医学院,广东,广州,510642 |
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| 基金项目： | 广东省自然科学基金，华南农业大学校长基金 |
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| 摘 要： | 采用台盼蓝计数、流式细胞仪分析等方法,离体研究玉米赤霉烯酮对小鼠胸腺上皮细胞增殖与细胞周期的影响,结果发现:不同质量浓度(1～25 mg/L)玉米赤霉烯酮对小鼠胸腺上皮细胞的增殖均具有显著抑制作用(P<0.05),并表现出与剂量和处理时间依赖性关系.高剂量(10～25 mg/L)ZEA使小鼠胸腺上皮细胞细胞周期显著阻滞于G2/M期(P<0.05),并存在剂量依赖性关系.这些结果表明,玉米赤霉烯酮对小鼠胸腺上皮细胞有直接毒害作用.
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| 关 键 词： | 玉米赤霉烯酮 细胞增殖 细胞周期 胸腺上皮细胞 小鼠 |
Cytotoxicity of zearalenone for thymic epithelial cells in mice |
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| LIANG Zi-sen,XU Li-na,Ma Yong-jiang,DENG Xian-bo,LI Ying,FAN Xiao-long,LI Yu-gu,NING Zhang-yong.Cytotoxicity of zearalenone for thymic epithelial cells in mice[J].Chinese Journal of Veterinary Science,2009,29(7). |
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| Authors: | LIANG Zi-sen XU Li-na Ma Yong-jiang DENG Xian-bo LI Ying FAN Xiao-long LI Yu-gu NING Zhang-yong |
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| Abstract: | To elucidate the effects of Zearalenone(ZEA) on proliferation and cell cycle of cultured thymic epithelial cells in mice,trypan blue staining and flow cytometric analysis were performed.At the concentrations from 1 to 25 mg/L,ZEA displayed a significant inhibitory action to proliferation of thymic epithelial cells in its dose-and timedependent manner.Higher doses(10-25 rag/L)ZEA could induce a profound increase in G2/M phase with arrest of thymic epithelial cells in the G2/M phase in a dose-dependent manner.In conclusion,ZEA could be assumed that there were toxic effects on the thymie epithelial cells of mice in vitro. |
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| Keywords: | zearaleone cell proliferation cell cycle thymic epithelial cells mouse |
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