| 可注射性壳聚糖基温敏性凝胶的制备及其生物相容性 |
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| 引用本文： | 闫继红,孙海梅,尚宏伟,张立新,路欣.可注射性壳聚糖基温敏性凝胶的制备及其生物相容性[J].吉林农业大学学报,2011,33(5):522-526. |
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| 作者姓名： | 闫继红 孙海梅 尚宏伟 张立新 路欣 |
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| 作者单位： | 首都医科大学基础医学院人体解剖与组织胚胎学系,北京,100069 |
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| 基金项目： | 北京市自然科学基金项目(3102010) |
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| 摘 要： | 以壳聚糖(Chitosan,CH)为基,加入不同配比的β-甘油磷酸钠(Glycerophosphate salt,GP)和羟乙基纤维素(Hydroxyethyl cellulose,HEC)制备成不同组成的壳聚糖基温敏性凝胶体系.研究了2种凝胶体系初始凝胶化温度、成凝胶化时间、在缓冲溶液中的溶胀性、对骨髓间充质干细胞的...
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| 关 键 词： | 壳聚糖 甘油磷酸钠 羟乙基纤维素 可注射性水凝胶 生物相容性 |
Preparation and Biocompatibility of Injectable Chitosan-Based Hydrogel |
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| YAN Ji-hong,SUN Hai-mei,SHANG Hong-wei,ZHANG Li-xin,LU Xin.Preparation and Biocompatibility of Injectable Chitosan-Based Hydrogel[J].Journal of Jilin Agricultural University,2011,33(5):522-526. |
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| Authors: | YAN Ji-hong SUN Hai-mei SHANG Hong-wei ZHANG Li-xin LU Xin |
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| Institution: | YAN Ji-hong,SUN Hai-mei,SHANG Hong-wei,ZHANG Li-xin,LU XinDepartment of Histology & Embryology,Capital Medical University,Beijing 100069,China |
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| Abstract: | The thermo-sensitive gel system based on chitosan-glycerophosphate salt(CH-GP) complex and chitosan-glycerophosphate salt-hydroxyethyl cellulose complex(CH-GP-HEC)were prepared in this study.Various factors affecting the properties of gels(the gelation time,the incipient gelation temperature(IGT),microstructure of the hydrogels,the swelling degrees of gels in buffer solutions,cell toxicity and the biocompatibility with bone mesenchymal stem cells(BMSC) were tested.The results showed the gels system can be q... |
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| Keywords: | chitosan(CH) glycerophosphate salt(GP) hydroxyethyl cellulose(HEC) injectable gel biocompatibility |
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