| 中药软膏剂体外透皮效果研究 |
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| 引用本文： | 韩天,马晓宇,杨英.中药软膏剂体外透皮效果研究[J].畜牧与饲料科学,2019,40(3):95-98. |
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| 作者姓名： | 韩天 马晓宇 杨英 |
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| 作者单位： | [1]内蒙古农业大学兽医学院,内蒙古呼和浩特010018;[2]农业农村部动物疾病临床诊疗技术重点实验室,内蒙古呼和浩特010018 |
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| 摘 要： | 为评价复方中药软膏剂中不同浓度的透皮剂药物氮酮对马属动物的透皮效果,首先利用中药复方水提醇沉浓缩液制备中药软膏剂,然后在软膏剂中分别加入2%、4%、5.5%、7%的透皮剂药物氮酮,以软膏剂中的淫羊藿苷成分作为标记物,利用酶标仪法测定经智能药物透皮仪处理后的马皮肤透过液中的标记物含量。结果表明,在中药软膏剂中加入5.5%的氮酮作为促渗剂,所获得的药物渗透效果最佳。该研究为马属动物中药软膏剂中透皮剂药物的选择提供了理论依据,也为复方中药透皮给药系统的研究提供了更为安全、有效、稳定的给药途径。
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| 关 键 词： | 中药软膏剂 吸光度 药物透皮剂 透过率 氮酮 |
| 收稿时间： | 2018-06-10 |
In Vitro Determination of Transdermal Permeation of a Traditional Chinese Medicine Ointment |
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| HAN Tian,MA Xiao-yu,YANG Ying.In Vitro Determination of Transdermal Permeation of a Traditional Chinese Medicine Ointment[J].Animal Husbandry and Feed Science,2019,40(3):95-98. |
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| Authors: | HAN Tian MA Xiao-yu YANG Ying |
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| Institution: | [1]College of Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China;[2]Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Diseases of Ministry of Agriculture and Rural Affairs,Hohhot 010018,China |
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| Abstract: | The objective of this study was to characterize the effect of azone,a commonly used penetration enhancer,on the in vitro percutaneous absorption of a compound traditional Chinese medicine ointment through horse skin.The ointment was prepared with the concentrates obtained with water-extraction and alcohol-precipitation method,and the different concentrations of azone (2%,4%,5.5% and 7%) were supplemented in the prepared ointment,respectively.The icariin,one of the main active ingredients of the prepared ointment,was used as an indicator to assess the penetration enhancing effect of azone.The content of icariin in penetrating fluid from horse skin treated by the smart drug transdermal device was determined using the microplate reader.The best penetration effect was observed when 5.5% of azone was added as a penetration enhancer in the ointment.This study provides a theoretical basis for the selection of penetration enhancers used in traditional Chinese medicine ointment for equine,and also provides a safer,more effective and more stable administration route for investigation of transdermal delivery system of compound traditional Chinese medicine. |
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| Keywords: | traditional Chinese medicine ointment absorbance penetration enhancer permeation rate azone |
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