The effect of bentonite concentration on the drug delivery efficacy of a pH-sensitive alginate/bentonite hydrogel |
| |
| Authors: | Seung-Taek Oh Oh-Jin Kwon Byoung-Chul Chun Jae-Whan Cho Jong-Shin Park |
| |
| Institution: | (1) Department of Polymer Engineering, The University of Suwon, Suwon, 445-743, Korea;(2) Department of Textile Engineering, Konkuk University, Seoul, 143-701, Korea;(3) Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-742, Korea;(4) Intelligent Textile System Research Center, Seoul, 151-742, Korea;(5) Research Institute for Agriculture and Life Sciences, Seoul, 151-742, Korea |
| |
| Abstract: | We produced a protein loaded, pH-sensitive alginate-bentonite hydrogel for wound dressings. Alginate is a nontoxic polysaccharide
with favorable pH-sensitive properties that make it useful for the intestinal delivery of protein drugs. However, the use
of alginate for drug delivery is limited by drug leaching and rapid dissolution of alginate at the higher pH, which may result
in lower entrapment efficiency and a burst in the release of entrapped protein drugs. To overcome these problems, we created
a novel cross-linked alginate-bentonite hydrogel by combining mineral-rich bentonite with the alginate matrix along with an
additive to ensure controlled release. We analyzed the gel in the drug loading process in an aqueous environment by looking
at the release profiles of a model protein drug (BSA) from the hydrogel at pH values of 4.5, 5.2 (skin area) and 7.4, 9.2
(wound area). The swelling ratio decreased with bentonite concentration, but did not fall below 6. The rate of drug release
was slowest at a pH value of 4.5 and fastest at a pH value of 9.2. The rate of drug release decreased with bentonite concentration.
The presence of bentonite prevents the rapid dissolution of alginate at the higher pH, ensuring the controlled release of
the entrapped drug. |
| |
| Keywords: | pH sensitive Alginate Bentonite Hydrogel Protein drug Oral delivery |
| 本文献已被 SpringerLink 等数据库收录！ |
|
