| MicroRNA在动物细胞和病毒间的调控作用 |
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| 引用本文： | 满朝来,于晓龙.MicroRNA在动物细胞和病毒间的调控作用[J].中国农学通报,2011,27(20):51-53. |
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| 作者姓名： | 满朝来 于晓龙 |
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| 作者单位： | 1. 哈尔滨师范大学生命科学与技术学院,哈尔滨,150025
2. 黑龙江省农业科学院畜牧研究所,哈尔滨,150086 |
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| 基金项目： | 黑龙江省自然基金重点项目“猪传染性胃肠炎病毒蛋白对miRNAs抑制作用与其致病性的研究”(ZJN0602-02) |
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| 摘 要： | 微小RNA(microRNA，miRNA)在介导病毒-动物细胞相互作用过程中发挥着重要的作用。miRNA通过诱导mRNA降解和抑制翻译等机制调节宿主细胞和病毒自身的靶基因，参与宿主细胞对病毒侵染的抵御和病毒对宿主的抵抗与逃避过程。本文从宿主来源miRNA对病毒的作用、病毒来源miRNA对宿主和病毒本身的作用，以及两种来源miRNA的相互作用关系等几个方面进行简要综述，同时对miRNA的应用前景也进行了初步探讨，以期对深入理解病毒-宿主间miRNA的相互作用机制和病毒病的防治提供新的思路与方法。
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| 关 键 词： | 病毒 宿主 microRNA 机制 应用 |
| 收稿时间： | 2011/4/27 0:00:00 |
| 修稿时间： | 5/6/2011 12:00:00 AM |
A Brief Discussion on Regulatory Functions of MicroRNAs between Animal Cell and Virus |
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| Man Chaola,Yu Xiaolong.A Brief Discussion on Regulatory Functions of MicroRNAs between Animal Cell and Virus[J].Chinese Agricultural Science Bulletin,2011,27(20):51-53. |
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| Authors: | Man Chaola Yu Xiaolong |
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| Institution: | Man Chaolai 1,Yu Xiaolong 2 ( 1 College of Life Science and Technology,Harbin Normal University,Harbin 150025,2 Institute of Animal Science,Heilongjiang Academy of Agricultural Sciences,Harbin 150086) |
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| Abstract: | MicroRNA plays important roles in the regulation of interaction between animal cell and virus. MicroRNA regulated target genes of host cell and virus through multiple mechanisms, such as, miRNA-induced mRNA degradation and translation inhibition. In this paper, the author mainly summarized the effects on virus of host-cell microRNAs, effects on host cell and virus of virus-encoded microRNAs, and interaction relation between the two sources microRNAs. Additionally, the using prospects of microRNA were also d... |
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| Keywords: | virus host microRNA mechanism use |
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