| 抗流感及禽流感病毒新药"帕拉米韦"研究进展 |
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| 引用本文： | 邱灵才,陈建新,方炳虎.抗流感及禽流感病毒新药"帕拉米韦"研究进展[J].中国兽药杂志,2006,40(6):36-40. |
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| 作者姓名： | 邱灵才 陈建新 方炳虎 |
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| 作者单位： | 华南农业大学兽医学院,广东省兽药研制与安全评价重点实验室,广东广州,510642 |
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| 摘 要： | 帕拉米韦（Peramivir）是一种以流感病毒表面糖蛋白神经氨酸酶为作用靶点的新型环戊烷类抗流感药物.本文综述了帕拉米韦的合成工艺、作用机理、药效学、药动学、临床研究及毒副作用等方面的研究进展.
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| 关 键 词： | 帕拉米韦 流感病毒 禽流感 神经氨酸酶抑制剂 |
| 文章编号： | 1002-1280（2006）06-0036-05 |
| 收稿时间： | 2006-01-13 |
| 修稿时间： | 2006-01-13 |
Research Advances on Peramivir:A Novel Drug of Anti-influenza Virus and Anti-avian Influenza Virus |
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| QIU Ling-cai,CHEN Jian-xin,FANG Bing-hu.Research Advances on Peramivir:A Novel Drug of Anti-influenza Virus and Anti-avian Influenza Virus[J].Chinese Journal of Veterinary Drug,2006,40(6):36-40. |
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| Authors: | QIU Ling-cai CHEN Jian-xin FANG Bing-hu |
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| Institution: | Department of Veterinary Medicine, South China Agriculture University, Guangzhou, Guangdong 510642 ; China |
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| Abstract: | Peramivir is a novel cyclopentane inhibitor for influenza virus neuraminidase. This review summarizes the research advances of peramivir on the mechanism of action, pharmacodynamics, pharrnacokinetics, clinical studies and side effects. |
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| Keywords: | peramivir influenza virus avian influenza virus neuraminidase inhibitors |
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