Effect of anti-ganglioside antibody in experimental Trypanosoma brucei infection in mice |
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| Authors: | Tsujimura Yoshie Watarai Shinobu Uemura Akiko Ohnishi Yoshihiro Kodama Hiroshi |
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| Institution: | Laboratory of Veterinary Immunology, Division of Veterinary Science, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan. |
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| Abstract: | The effect of antibody against ganglioside antigen on Trypanosoma brucei parasites was examined in vitro and in vivo using anti-ganglioside GM1 (AGM-1) monoclonal antibody. The antibody showed complement-dependent cytotoxicity against T. brucei with mouse complement. Furthermore, mice given AGM-1 were challenged intraperitoneally with T. brucei. Although all non-treated control mice died within six days after infection, all of AGM-1-injected mice had survived by six days post-infection. These data suggest that antibody against ganglioside antigen on T. brucei has potential in protection against T. brucei infection. |
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| Keywords: | Anti-ganglioside antibody Ganglioside Protozoan disease Trypanosoma brucei |
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