Properties of a Complex of Iron and a Sorbitol-Gluconic Acid Polymer for Treatment of Piglet Anaemia |
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| Authors: | H Carlsson S Lindvall B Thafvelin |
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| Institution: | Product Development Department, Astra-Ewos AB, the Research Laboratories, Astra Pharmaceuticals AB, Sodertalje and the Animal Health Service Department, Swedish Meat Marketing Association, S-151 85 Stockholm, Sweden |
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| Abstract: | The properties of a complex of iron and a sorbitol-gluconic acid polymer useful for intramuscular treatment of piglet anaemia have been studied. In rabbits it is well absorbed from muscle and a small percentage (8 %) of the administered iron is excreted in the urine. A satisfactory utilization of the administered iron for haemoglobin synthesis has been shown in rats. A high degree of tolerance in piglets was observed also for the highest test doses, 600 mg iron per kg body weight. The clinical utilization was compared to that of iron-dextran using a total of 209 piglets and a dose of 200 mg iron for each animal. Five of these piglets were lost, but these deaths cannot be correlated to the treatment. Of the remaining animals 102 were treated with ISGP and 102 with iron-dextran, and the anaemia-preventing effect was similar for these 2 iron complexes. |
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| Keywords: | haemoglobin synthesis iron complexes iron-dextran iron-sorbitol-gluconic acid polymer parenteral iron piglet anaemia tolerance |
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