| 《园艺学报》征稿简则 |
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| 摘 要： |
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Prognostic role of biomarkers applied to hepatocellular carcinoma patients treated with orthotopic liver transplantation |
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| Authors: | CHEN Xu-jian WU Li-ming XU Xiao-bo FENG Xiao-wen XIE Hai-yang ZHANG Min SHEN Yan WANG Wei-lin LIANG Ting-bo ZHENG Shu-sen |
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| Institution: | Key Laboratory of Combined Multi-Organ Transplantation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China. E-mail: 76cxj@sina.com |
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| Abstract: | AIM:To investigate the prognostic value of biomarkers on predicting recurrence of hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLT). METHODS:Fifty patients with HCC who underwent OLT between April 2002 and November 2005 with a minimum clinical follow up of 12 months were included in this retrospective study. We examined immunohistochemical expression of E-cadherin with β-catenin, Ki-67 proliferative index and analyzed the correlation between these biomarkers with recurrence and survival, along with the main clinical-pathological variables.RESULTS:Only at univariate analysis, TNM, portal vein tumor thrombi were valuable on predicting recurrence and survival time (P<0.05), and preoperative serum AFP correlate to recurrence only at multivariate analysis (OR=2.552, P<0.05). Lower membrane expression of E-cadherin, nuclear β-catenin localization and high Ki-67 index showed notable significance on predicting recurrence and survival time at univariate analysis, as well at multivariate analysis, all P<0.01. The membrane expression of β-catenin did not correlate to the prognosis (P>0.05).CONCLUSION:These three biomarkers might have potential as a tumor prognostic marker for predicting recurrence of HCC after OLT and perhaps are better than the clinical-pathological variables. |
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| Keywords: | Liver neoplasms Liver transplantation Recurrence Cadherins β-catenin Antigens Ki-67 |
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