The effect of furanoheliangolides from Tithonia diversifolia on superoxide anion generation in human neutrophils |
| |
| Authors: | Herrera J Troncone G Sánchez M R Miguel V Lopez S E |
| |
| Institution: | Departamento de Química, Universidad Simón Bolívar, Apartado 8900, Caracas 1080A, Venezuela. cherrera@usb.ve |
| |
| Abstract: | Four known lactones were isolated from Tithonia diversifolia: furanoheliangolides 1,3-dihydroxy-3,10-epoxy-8-(-2-methylpropanoyloxy)-germacra-11(13)-ene-6,12-olide (1), 1,3-dihydroxy-3,10-epoxy-8-(2-methylpropanoyloxy)-germacra-4,11(13)-diene-6,12-olide (2), 1,3-dimethoxy-3,10-epoxy-8-(2-methylpropanoyloxy)-germacra-4,11(13)-diene-6,12-olide (3) and, observed in natural source for the first time, furanoheliangolide 1-hydroxy-3-methoxy-3,10-epoxy-8-(2-methylpropanoyloxy)-germacra-4,11(13)-diene-6,12-olide (4). The activity of sesquiterpene lactones on superoxide anion (O(2)(o)(-)) generation from PMA-activated neutrophils was evaluated. Compound 1 did not show a full dose dependent behavior. The IC(100) was 8+/-1, 12+/-1, and 17+/-3 microM for 2 to 4, respectively. |
| |
| Keywords: | Tithonia diversifolia Anti-inflammatory Superoxide anion |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
