| 白鲜碱体外抗白色念珠菌活性研究 |
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| 作者姓名： | 梁晓英 郭娜 王丽莎 金晶 石建平 陆慧君 邓旭明 于录 |
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| 作者单位： | 1. ;2. 吉林大学农学部;3. 吉林大学;4. 吉林大学人兽共患病研究所; |
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| 摘 要： | 白色念珠菌等真菌是能够引起人类及动物患病的重要致病菌。本实验测定了白鲜碱对临床22株临床分离氟康唑耐药白色念珠菌的最小抑菌浓度（MIC），采用棋盘式微量稀释实验测定了两药联合应药的分级抑制浓度指数（ractional inhibitory concentration index，FICI）值。结果表明，白鲜碱有较好的抗白色念珠菌活性且与氟康唑有协同作用。
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| 关 键 词： | 白鲜碱 |
Study on in Vitro Antifungal Activity of Dictamnine against Candida albicans |
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| Authors: | Liang Xiaoying Guo N Wang Lish Jin Jing Shi Jianping
Lu Huijun Deng Xuming Yu Lu |
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| Abstract: | Candida albicans (C. albicans) and other fungi an important human and veterinary pathogens. The minimal inhibitory concentration (MIC) of dictamnine alone and in combination with fluconazole (FLC) against clinical 22 clinical Candida albicans were tested, and checkerboard assay was used to analyzed the ractional inhibitory concentration index (FICI) of the combination of dictamnine and FLC. The result showed that dictamnine had good antifungal activity alone and in combination with FLC against Candida albicans. |
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| Keywords: | dictamnine fungi antifungal activity synergism |
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