| 大肠杆菌不耐热肠毒素对狂犬病病毒减毒疫苗株粘膜免疫效应的增强作用 |
| |
| 引用本文： | 张茂林,刘红丽,余兴龙,涂长春,扈荣良,邹啸环,郭学军,殷震.大肠杆菌不耐热肠毒素对狂犬病病毒减毒疫苗株粘膜免疫效应的增强作用[J].中国兽医学报,2004,24(1):39-42. |
| |
| 作者姓名： | 张茂林 刘红丽 余兴龙 涂长春 扈荣良 邹啸环 郭学军 殷震 |
| |
| 作者单位： | 1. 解放军军需大学军事兽医研究所,吉林,长春,130062
2. 解放军军需大学,中心实验室,吉林,长春,130062 |
| |
| 基金项目： | 国家自然科学基金资助项目 ( 3 990 0 10 8) |
| |
| 摘 要： | 将狂犬病病毒 SRV9减毒疫苗与大肠杆菌不耐热肠毒素 (L T)混合 ,分别经口腔滴入、灌胃、灌肠等途径免疫小鼠。通过检测外周血淋巴细胞特异性转化率、CTL反应、Ig G、Ig A、SIg A等免疫指标 ,并结合攻毒保护 ,探讨了狂犬病病毒经消化道不同途径接种产生的免疫效果以及 L T在粘膜免疫中的作用。结果表明 :肠道接种组的狂犬病病毒特异性免疫应答水平高于口腔和胃接种组的免疫应答水平 ,L T可增强狂犬病病毒减毒疫苗诱导的免疫应答反应
|
| 关 键 词： | 大肠杆菌不耐热肠毒素 狂犬病病毒减毒疫苗 粘膜免疫 |
| 文章编号： | 1005-4545(2004)01-0039-04 |
| 修稿时间： | 2003年3月19日 |
Enhancing Effect of Heat-labile Toxin on Mucosal Immunity of Attenuated Rabies Vaccine |
| |
| ZHANG Mao-lin,LIU Hong-li,YU Xing-long,TU Chang-chun.Enhancing Effect of Heat-labile Toxin on Mucosal Immunity of Attenuated Rabies Vaccine[J].Chinese Journal of Veterinary Science,2004,24(1):39-42. |
| |
| Authors: | ZHANG Mao-lin LIU Hong-li YU Xing-long TU Chang-chun |
| |
| Institution: | ZHANG Mao-lin~1,LIU Hong-li~1,YU Xing-long~1,TU Chang-chun~ |
| |
| Abstract: | Mice were inoculated with SRV_9 and LT(heat-labile toxin derived from E.coli) by direct oral cavity instillation,stomach delivery and rectal instillation,respectively.The immune respone and the role of LT were evaluated based on the detection of specific lymphocyte proliferation in vitro,cytotoxin T cells response,titer of serum IgG,mucosal secretory(SIgA) neutralization index of serum antibody and protection rates after challenge.The results showed that the immune response evoked by rectal instillation was higher than that of others.The immune responses in groups with LT were higher than without LT. |
| |
| Keywords: | heat-labile toxin attenuated rabies vaccine mucosal immunity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
