| 超高效液相色谱-串联质谱法检测扶正解毒散剂中非法添加物喹乙醇、乙酰甲喹 |
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| 引用本文： | 章安源,章安雯,牛华星,陈玲,张琦.超高效液相色谱-串联质谱法检测扶正解毒散剂中非法添加物喹乙醇、乙酰甲喹[J].中国兽药杂志,2019,53(10):33-39. |
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| 作者姓名： | 章安源 章安雯 牛华星 陈玲 张琦 |
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| 作者单位： | 山东省兽药质量检验所,,,山东省兽药质量检验所, |
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| 摘 要： | 建立了扶正解毒散中非法添加喹乙醇、乙酰甲喹检测的UPLC-MS/MS方法。样品经60%乙腈提取稀释后,采用ACQUITYUPLCRBEHC18色谱柱为分离柱,质谱正离子扫描分析测定。结果显示,喹乙醇、乙酰甲喹在5~200ng/mL的范围内线性关系良好(R2=0.9984,R2=0.9995);样品检出限为25μg/mL,定量限为50μg/mL。在80、100、120μg/mL添加水平的回收率为90%~103%,批内批间变异系数均小于10%。本方法灵敏、快速、重现性好,适用于扶正解毒散中非法添加喹乙醇、乙酰甲喹的检测。
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| 关 键 词： | 喹乙醇 乙酰甲喹 扶正解毒散 超高效液相-串联质谱法 |
| 收稿时间： | 2019/7/15 0:00:00 |
| 修稿时间： | 2019/9/18 0:00:00 |
Determination of Olaquindox and Mequindox Illegally Added in Fuzhengjiedusan by UPLC-MS/MS |
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| ZHANG An-yuan,ZHANG An-wen,NU Hua-xing,CHEN Ling,ZHANG Qi.Determination of Olaquindox and Mequindox Illegally Added in Fuzhengjiedusan by UPLC-MS/MS[J].Chinese Journal of Veterinary Drug,2019,53(10):33-39. |
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| Authors: | ZHANG An-yuan ZHANG An-wen NU Hua-xing CHEN Ling ZHANG Qi |
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| Institution: | (Institute of Veterinary Drug Quality Inspection of ShandongProvince,Jinan 250022, China;Zaozhuang Vocational College,Shandong, Zaozhuang 277100,China) |
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| Abstract: | ZHANG An-yuan;ZHANG An-wen;NU Hua-xing;CHEN Ling;ZHANG Qi(Institute of Veterinary Drug Quality Inspection of ShandongProvince,Jinan 250022, China;Zaozhuang Vocational College,Shandong, Zaozhuang 277100,China) |
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| Keywords: | olaquindox mequindox Fuzhengjiedu san UPLC-MS/MS |
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