Antioxidant and 15-lipoxygenase inhibitory activity of rotenoids, isoflavones and phenolic glycosides from Sarcolobus globosus |
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| Authors: | Wangensteen Helle Miron Anca Alamgir Mahiuddin Rajia Sultana Samuelsen Anne Berit Malterud Karl Egil |
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| Institution: | Division of Pharmacognosy, Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P. O. Box 1068 Blindern, N 0316 Oslo, Norway. helle.wangensteen@farmasi.uio.no |
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| Abstract: | From Sarcolobus globosus, two rotenoids (villosinol and 6-oxo-6a,12a-dehydrodeguelin), one isoflavone (genistin) and four phenolic glycosides (vanillic acid 4-O-beta-d-glucoside, glucosyringic acid, tachioside and isotachioside) were identified for the first time from this species. Extracts and compounds from S. globosus were evaluated for their DPPH radical scavenging and 15-lipoxygenase (15-LO) inhibitory activities. All tested rotenoids were found to inhibit 15-LO, while they lacked DPPH radical scavenging effect. |
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| Keywords: | Sarcolobus globosus Rotenoids Isoflavones DPPH 15-Lipoxygenase Antioxidant |
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