| 恩诺沙星纳米粒的制备及稳定性研究 |
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| 引用本文： | 龚露旸,杨先乐,胡鲲.恩诺沙星纳米粒的制备及稳定性研究[J].安徽农业科学,2009,37(5):2019-2021. |
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| 作者姓名： | 龚露旸 杨先乐 胡鲲 |
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| 作者单位： | 上海海洋大学国家水生动植物病原库,上海,201306;上海海洋大学国家水生动植物病原库,上海,201306;上海海洋大学国家水生动植物病原库,上海,201306 |
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| 基金项目： | 国家“十一五”科技支撑计划项目(2006BAD03B04) |
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| 摘 要： | 目的]优化恩诺沙星纳米粒制备参数，考察其稳定性。方法]以壳聚糖为辅料，采用离子交联法和冷冻干燥法制备恩诺沙星壳聚糖纳米粒，以包封率为参考指标设计正交试验，确定优化制备参数，以透射电镜观察其表观特征，并对其热稳定性及紫外稳定性进行考察。结果]以优化参数制备的恩诺沙星壳聚糖纳米粒平均粒径237．4nm平均包封率（71．9±2．2）％，平均载药量（12．4±0．6）％。与原料药相比，4h热降解率和紫外降解率分别减少了38．4％和13．3％。结论]离子交联法和冷冻干燥法适用于制备恩诺沙星壳聚糖纳米粒，其产品具有良好的热稳定性和紫外稳定性。
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| 关 键 词： | 思诺沙星 壳聚糖 纳米粒 热稳定性 紫外稳定性 |
Study on the Preparation and the Stability of Enrofloxacin Nanoparticles(ENR-NPs) |
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| GONG Lu-yang et al.Study on the Preparation and the Stability of Enrofloxacin Nanoparticles(ENR-NPs)[J].Journal of Anhui Agricultural Sciences,2009,37(5):2019-2021. |
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| Authors: | GONG Lu-yang |
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| Institution: | GONG Lu-yang et al (State Collection Center of Aquatic Pathogen,Shanghai Ocean University,Shanghai 201306) |
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| Abstract: | Objective] The research aimed to optimize the preparing method of enrofloxacin nanoparticles(ENR-NPs) and investigate its stability.Method] ENR-NPs was prepared using freeze-drying and ionic gelation method with chitosan.The thermal and ultraviolet stability were measured at the same time.Result] The nanoparticles observed by TEM were spherical with a mean particle size of 237.4 nm.The encapsulation efficiency and drug loading of ENR-NPs were(71.9±2.2)% and(12.4±0.6)%.The total thermal and ultraviolet degradation of ENR-NPs in 4 h were decreased by 38.4% and 13.3% compared to raw ENR.Conclusion] Ionic gelation and freeze-drying method ia applicable to the preparation of ENR-NPs and its product has characteristic of good thermal and ultraviolet stability. |
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| Keywords: | Enrofloxacin Chitosan Nanoparticles Thermal stability Ultraviolet stability |
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