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兔出血症病毒(RHDV)及其免疫复合物在兔体内的动态分布
引用本文:王林川,钟绍周.兔出血症病毒(RHDV)及其免疫复合物在兔体内的动态分布[J].江西农业大学学报,1990,12(1):73-77.
作者姓名:王林川  钟绍周
作者单位:江西农业大学牧医系 (王林川),江西农业大学牧医系(钟绍周)
摘    要:用RHDV人工感染易感兔,每隔4小时剖杀一组,整个病程大多为24小时,且病变典型.血凝试验查得,主要脏器病毒出现时间顺序是肝(攻毒后12小时)、脾、心、肾(16小时)、肺(20小时);病程后期,病毒含量从高到低依次为肝、脾、肺、肾、心。免疫荧光间接法检查感染兔各脏器,发现病毒经肌注兔体后4小时,即可定位于肝细胞,并在肝细胞核内复制增殖;兔感染病毒后16小时,在肝、脾、肾小球中可检出有免疫复合物沉着或抗体附着。电镜检查,肝细胞核内发现有病毒粒子,直径为25~30nm,细胞结构破坏严重。作者认为,RHDV 是一种 DNA 病毒;免疫复合物引起的免疫损伤及肝细胞结构、功能被破坏是兔发生病毒性出血症的重要原因。

关 键 词:  出血症病毒  病毒病  免疫复合物

THE DYNAMIC DISTRIBUTION OF THE RABBIT HEMORRHAGIC DISEASE VIRUS(RHDV)AND ITS IMMUNE COMPLEXES IN THE RABBIT BODY
Wang Linchuan Zhong Shaozhou.THE DYNAMIC DISTRIBUTION OF THE RABBIT HEMORRHAGIC DISEASE VIRUS(RHDV)AND ITS IMMUNE COMPLEXES IN THE RABBIT BODY[J].Acta Agriculturae Universitis Jiangxiensis,1990,12(1):73-77.
Authors:Wang Linchuan Zhong Shaozhou
Abstract:Most rabbits died in 24 hours after being infected by RHDV,and thesymptoms were clear.In the test,a group of rabbits were killed every 4hours from 0 to 24 hours.HA test directed,the order of the appearance ofRHDV in the main tissues was liver(12 hours after infection ),spleen,heart,kidney(16 hours),lung(20 hours);the order of the RHDV contentin the main tissues before death was liver,spleen,lung,kidney,heart.Bythe inderect immunofluorescence technique,it was found that RHDV could bedetected in the liver-cells four hours after the muscle injection with RHDV,and it reproduced in the liver-cell's nuclei,and there were immune complexesor antibodies deposits in or adhered to the liver-cells,spleen-cells,andglomeruli of the kidney 16 hours after the rabbit being infected.The electr-omicroscope technique showed,the virus particles were roughly spherical,about 25-30 nm in diameter,without envelope,and the livercells were destr-oyed seriously.The auther points out,RHDV is a kind of DNA virus;theimmune damage caused by the immune complexes and the destruction of liver-cells' structure and function were the major causes of viral hemorrhagic dis-ease in rabbits.
Keywords:Rabbit hemorrhagic disease virus  Viral hemorrhagic disease of rabbit  Immune complex  Dynamic distribution
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