| 左卡尼汀对D-半乳糖致衰老小鼠抗氧化作用的研究 |
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| 引用本文： | 栾海云.左卡尼汀对D-半乳糖致衰老小鼠抗氧化作用的研究[J].湖北农业科学,2012(1):129-130,135. |
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| 作者姓名： | 栾海云 |
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| 作者单位： | 滨州医学院药学院药物研究所 |
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| 摘 要： | 为了研究左卡尼汀(L-carnitine,LC)对D-半乳糖所致衰老小鼠的抗氧化作用,试验将50只小鼠随机分成5组,即空白对照组、模型组和左卡尼汀治疗组0.25、0.50、1.00 g/(kg.d)],采用D-半乳糖复制亚急性衰老小鼠模型,试验6周后处死小鼠,测定其血浆、脑组织及肝脏中的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)含量。试验结果显示,左卡尼汀能显著提高衰老小鼠血清、脑组织及肝脏中的SOD、GSH-Px活性,降低MDA含量,且呈剂量依赖性。表明左卡尼汀有一定的抗衰老作用,其机制可能与抗氧化作用有关。
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| 关 键 词： | 左卡尼汀(L-carnitine LC) 抗衰老 D-半乳糖 |
The Antioxidant Effect of L-carnitine on D-galactose Induced Aging Mice |
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| LUAN Hai-yun.The Antioxidant Effect of L-carnitine on D-galactose Induced Aging Mice[J].Hubei Agricultural Sciences,2012(1):129-130,135. |
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| Authors: | LUAN Hai-yun |
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| Institution: | LUAN Hai-yun(Institute of Material Medical,College of Pharmacy,Binzhou Medical University,Yantai 264003,Shandong,China) |
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| Abstract: | 50 mice were randomly allocated to 5 groups to study the antioxidant effects of L-carnitine on D-galactose induced aging mice.Apart from a control group,D-galactose model group,the LC treatment groups were at three level such as 0.25,0.50 and 1.00 g/kg·d.Using the subacute D-galactose induced aging model,the mice were killed after 6 weeks of experiment and detected the level of SOD,GSH-Px and MDA in the blood,brain and liver tissue.The results showed that the activity of SOD and GSH-Px in blood,brain and liver tissue were significantly increased after treated with L-carnitine,while the contents of MDA were decreased.It indicated that the L-carnitine had anti-aging effects in mice,and the mechanism might be correlated with its antioxidation. |
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| Keywords: | L-carnitine anti-aging D-galactose |
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