| 哺乳动物早期胚胎的剂量补偿作用及其对发育的影响 |
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| 引用本文： | 王正朝,潘晓燕,庞训胜.哺乳动物早期胚胎的剂量补偿作用及其对发育的影响[J].家畜生态,2006(6). |
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| 作者姓名： | 王正朝 潘晓燕 庞训胜 |
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| 作者单位： | 南京农业大学动物科技学院 江苏南京21009(王正朝，潘晓燕)，安徽科技学院 安徽蚌埠233100(庞训胜) |
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| 基金项目： | 安徽省自然科学基金(03041203)资助 |
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| 摘 要： | 剂量补偿是使X连锁基因的表达水平在两性间达到平衡的过程。哺乳动物是通过随机失活雌性的一条X染色体实现剂量补偿。X染色体失活开始于X染色体失活中心(XIC),然后传播到整条染色体。Xist基因定位于XIC中,参与X染色体失活的启动。本文主要通过分析雄核生殖胚胎、雌核生殖胚胎和正常胚胎发育中X连锁基因表达,概括了X染色体失活(XCI)在哺乳动物早期胚胎发育中作用,综述了哺乳动物早期胚胎的剂量补偿作用及其对发育的影响。
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| 关 键 词： | 早期胚胎 X染色体失活(XCI) 基因印迹 剂量补偿 |
Dosage Compensation of Early Embryo and Its Effect on the Development of Mammals |
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| WANG Zheng-chao,PAN Xiao-yan,PANG Xun-sheng.Dosage Compensation of Early Embryo and Its Effect on the Development of Mammals[J].Ecology of Domestic Animal,2006(6). |
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| Authors: | WANG Zheng-chao PAN Xiao-yan PANG Xun-sheng |
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| Abstract: | Dosage compensation is the process by which the levels of X-linked gene expression is equalized between the sexes.In mammals,it is achieved by random inactivating one of the two X chromosomes in the female.X inactivation starts at the X-inactivation center(XIC) and spreads throughout the chromosomes.The Xist gene maps to the XIC region on the X chromosome and is thought to be involved in the initiation of inactivation.X-linked gene expression in androgenones,gynogenones,parthenogenones and normal Embryos were analysed in this article;Whilst it also summaried the effect of X chromosome inactivation(XIC) on the development of early embryos in mammals,and reviewed the dosage compensation of early embryo and its effect on the development in mammals |
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| Keywords: | Early embryo X chromosome inactivation(XIC) Gene imprinting Dosage compensation |
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