Feline Precursor. porphyria, characterized by persistent delta. Aminolevulinic aciduria |
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| Authors: | A D J Watson |
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| Institution: | Department of Veterinary Clinical Sciences, The University of Sydney, New South Wales 2006,. Australia. |
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| Abstract: | A female domestic shorthaired cat had frequent seizures and vague gastrointestinal signs. Lead poisoning was suspected because of increased urinary delta aminolevulinic acid concentration. However, abnormalities continued despite repeated chelation therapy and blood lead concentration was normal. Delta aminolevulinic aciduria persisted, but concentrations of porphobilinogen in urine and of porphyrins in blood, urine and faeces were normal. An inherited porphyric disorder was suspected, involving deficiency of aminolevulinic acid dehydrase, an enzyme active in haem biosynthesis. Accumulation of aminolevulinic acid in vivo could explain the observed signs. |
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