| 6-羟基多巴胺致帕金森病大鼠模型的建立与评价 |
| |
| 引用本文： | 李泽鸿,陶英楠,刘继阳,张帆.6-羟基多巴胺致帕金森病大鼠模型的建立与评价[J].中国畜牧兽医,2012,39(12):162-165. |
| |
| 作者姓名： | 李泽鸿 陶英楠 刘继阳 张帆 |
| |
| 作者单位： | 1. 吉林农业大学生命科学学院,吉林长春,130118
2. 吉林农业大学生命科学学院,吉林长春130118;柳河县烟草公司,吉林柳河130060 |
| |
| 基金项目： | 吉林省教育厅"十一五"科学技术研究项目课题 |
| |
| 摘 要： | 应用6-羟基多巴胺(6-hydroxydopamine,6-OHDA)制造帕金森病(Parkinson’s disease,PD)大鼠模型,建模成功后采用组织化学方法检测模型黑质多巴胺能神经元变化,并从行为学及黑质多巴胺能神经元数目的变化对模型进行综合评价。取Wistar大鼠,采用立体定向法,进行右侧纹状体区6-OHDA 双点注射。结果表明,6-OHDA纹状体注射可成功的诱导帕金森大鼠模型。
|
| 关 键 词： | 帕金森病 6-羟基多巴胺 多巴胺能神经元 |
| 收稿时间： | 2012-06-04 |
The Establishment and Evaluation of Rats Model of the Parkinson's Disease Cased by 6-OHDA |
| |
| LI Ze-hong
,
TAO Ying-nan
,
LIU Ji-yang
,
ZHANG Fan.The Establishment and Evaluation of Rats Model of the Parkinson's Disease Cased by 6-OHDA[J].China Animal Husbandry & Veterinary Medicine,2012,39(12):162-165. |
| |
| Authors: | LI Ze-hong TAO Ying-nan LIU Ji-yang ZHANG Fan |
| |
| Institution: | 1. College of Life Science, Jilin Agricultural University, Changchun 130118,China;2. Tobacco Company of Liuhe County, Liuhe 130060,China |
| |
| Abstract: | Appplicate the 6-hydroxydopanine(6-OHDA) to manufacture the rat’s model of Parkinson’s disease (PD), through the organizations of chemical method could dectect and evaluate the model comprehensivly from the changes of the behaviour and the number changes of dopaminergic neurons of nigra after the model succeed. Fetch Wistar rat by using stereotactic method, and then inject right striatum 6-OHDA into two-point. This study showed that 6-OHDA injection striatum could induce the rat model of Parkinson’s sucessfully. |
| |
| Keywords: | Parkinson’s disease 6-hydroxydopamine dopaminergic neurons |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国畜牧兽医》浏览原始摘要信息 |
| 点击此处可从《中国畜牧兽医》下载免费的PDF全文 |
|
