| 高钠所致肺动脉高压肉鸡肺细小动脉病理改变的图象分析 |
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| 引用本文： | 李锦春,王小龙,孙卫东,张克春.高钠所致肺动脉高压肉鸡肺细小动脉病理改变的图象分析[J].畜牧兽医学报,2000,31(5):441-447. |
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| 作者姓名： | 李锦春 王小龙 孙卫东 张克春 |
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| 作者单位： | 南京农业大学动物医学院,南京,210095 |
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| 基金项目： | 国家自然科学基金资助项目! (395 70 5 4)，江苏省“九·五”农业重点攻关资助项目! (BE96 436 ) |
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| 摘 要： | 240羽健康AA肉鸡随机均分为试验1组，试验2组和对照组，从8日龄起分别饮用含Na^ 为0.06%、0.12%和0.0%的饮水，其它饲养管理条件相同，分别于12、19、30、34、39日龄抽取各组参试鸡，以右心室（Right ventricle,RV)与全心室（Total ventrcle,TV)的重量比（RV／TV）作为判定肺动脉高压的依据，用图象分析仪对肺细小动脉病理变化作定量检测。结果表明：34、39日龄时，试验1组和试验2组管壁面积／管总面积和中膜厚度占外径百分值明显大于对照组，肺小动脉密度明显低，其RV／TV值均大于0.25，表明试验组肉鸡发生了肺动脉高压。由此可见，由高钠引起肉鸡肺细小动脉血管重构的病变可能参与了肺动脉高压的形成过程。
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| 关 键 词： | 肺动脉高压 肺细小动脉 肉用鸡 病理 高钠 |
STUDY ON HISTOPATHOLOGY OF PULMONARY ARTERIOLES OF BROILERS WITH Na+-INDUCED PULMONARY HYPERTENSION BY USING THE MICROSCOPIC IMAGE ANALYSIS PROGRAM |
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| Li Jingchun,Wang Xiaolong,Sun Weidong,Zhang Kechun.STUDY ON HISTOPATHOLOGY OF PULMONARY ARTERIOLES OF BROILERS WITH Na+-INDUCED PULMONARY HYPERTENSION BY USING THE MICROSCOPIC IMAGE ANALYSIS PROGRAM[J].Acta Veterinaria et Zootechnica Sinica,2000,31(5):441-447. |
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| Authors: | Li Jingchun Wang Xiaolong Sun Weidong Zhang Kechun |
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| Abstract: | WT5BZ]Two hundred and forty broilers were divided into three groups evenly and treated with 0.0%,0 06% and 0 12%Na (from NaCl)in their drinking water,respectively from 7 to 39 days of age.Birds were selected for histopathological evaluation of pulmonary arterioles from three groups.The ratio of right ventricle to total ventricle weight(RV/TV)was determined as index of pulmonary hypertension(PH).The measurement of ratio of vessel wall area(WA)to vessel total area(TA)and mean medial thickness in pulmonary arterioles (mMTPA) was accomplished by using the microscopic image analysis program.The results indicated that the ratio of WA/TA and the mMTPA of experimental groups were higher than that of control group.The density of arterioles in experimental groups was lower than that of control group at 34,39 days of age.The ratio of RV to TV in experimental groups in which PH has occurred was higher than 0.25.It can be concluded that the remodelling in the pulmonary arteriole structure may be one of participants in the forming of the pathological process of PH induced by Na from drinking water in broilers. |
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| Keywords: | Na Pulmonary hypertension(PH) Pulmonary arteriole Broiler Microscopic image analysis program |
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