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| 神经素的研究进展 | |
| 引用本文： | 吴云舟,刘皙洁,张磊,李德山.神经素的研究进展[J].东北农业大学学报,2009,40(5). |
| 作者姓名： | 吴云舟 刘皙洁 张磊 李德山 |
| 作者单位： | 1. 东北农业大学动物医学学院,哈尔滨,150030 2. 黑龙江省肿瘤医院,哈尔滨,1500403 3. 东北农业大学生命科学学院,哈尔滨,150030 |
| 摘 要： | 神经素是一个由33个氨基酸组成的神经肽,在不同物种中都有较高的保守性,在脑、内分泌组织、神经分泌组织和神经组织中特异表达。SN的前体蛋白是成熟的神经递质,被命名为Secretogranin Ⅱ(SgⅡ),属于嗜铬类蛋白家族。SN前体mRNA的表达水平很大程度上由细胞的去极化所调节,也可作为长期和瞬时神经活性变化的有用标记。在病理生理条件下,尤其是在细胞缺氧时,SN可以在非内分泌组织中表达。SN可特异、高效地吸引单核细胞,嗜曙红细胞形成浓度梯度,并且有促进血管生长的作用。因此,SN可介导神经性炎症反应,并且在由缺氧导致的局部缺血的症状中,SN可能与神经血管生成有关。 |
| 关 键 词： | 神经多肽 血管生成 分泌粒蛋白 |
Research advance of secretoneurin |
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| WU Yunzhou,LIU Xijie,ZHANG Lei,LI Deshan.Research advance of secretoneurin[J].Journal of Northeast Agricultural University,2009,40(5). | |
| Authors: | WU Yunzhou LIU Xijie ZHANG Lei LI Deshan |
| Institution: | WU Yunzhou1,LIU Xijie1,ZHANG Lei2,LI Deshan3 (1. College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China,2. Heilongjiang Tumour Hospital,Harbin 150040,3. College of Life Sciences,Northeast Agricultueal University,China) |
| Abstract: | Secretoneurin (SN) is a neuropeptide, which is comprised by 33 amino acids. SN is highly conserved between different species especially and specifically expressed in brain, endocrine, neuroendocrine and neuronal tissues. The precursor protein of SN is a neurotransmitter, which is named secretogranin Ⅱ, belongs to chromogranin family. The expression level of ProSN mRNA is significantly regulated by cell depolarization, could be used as a marker for both rapid and long-lasting changes in neuronal activity. Under pathophysiological conditions, especially in cellular hypoxia condition, SN could be expressed in non-endocrine tissues. SN could specifically attract the monocytes, eosinophils to form a concentration gradient and play a role as an angiogenic cytokine. Thus, SN could mediate the neurogenic inflammation and might have functions in neo-vascularisation in ischemic diseases (driven by hypoxia). |
| Keywords: | neuropeptide angiogenic secretogranin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |