| 新生儿Fc受体的研究进展 |
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| 引用本文： | 陈丽颖,王艳玲,杨国宇,胡广超.新生儿Fc受体的研究进展[J].河南农业大学学报,2007,41(4):469-474. |
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| 作者姓名： | 陈丽颖 王艳玲 杨国宇 胡广超 |
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| 作者单位： | 河南农业大学牧医工程学院,河南,郑州,450002 |
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| 摘 要： | 新生儿Fc受体(FcRn)是负责上皮细胞主动转运免疫球蛋白IgG的受体.IgG是初乳中含量最丰富的免疫球蛋白成分,哺乳动物新生儿的免疫力主要依赖于从母体获得IgG,而母源IgG向乳汁中的分泌以及被新生儿摄取均需要穿越上皮屏障,这一过程就是FcRn的胞转作用.本文对FcRn的特性、转运机制及其研究进展进行综述.
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| 关 键 词： | FcRn IgG 转运 上皮屏障 |
| 文章编号： | 1000-2340（2007）04-0469-06 |
| 收稿时间： | 2007-01-11 |
| 修稿时间： | 2007年1月11日 |
Advances in Research of Neonatal Fc Receptor |
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| CHEN Li-ying,WANG Yan-ling,YANG Guo-yu,HU Guang-chao.Advances in Research of Neonatal Fc Receptor[J].Journal of Henan Agricultural University,2007,41(4):469-474. |
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| Authors: | CHEN Li-ying WANG Yan-ling YANG Guo-yu HU Guang-chao |
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| Institution: | Engineering College of Animal Husbandry and Veterinary Sciences, Henan Agricultural University, Zhengzhou 450002, China |
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| Abstract: | Neonatal Fc receptor(FcRn) plays a critical role in active transportation of Immunoglobulin G across the epithelium.IgG is the most abundant Ig component in milk,upon which mammalian neonates acquire passive protection against pathogens.This is a process of transcytosis by FcRn through which maternal IgG is transported across epithelial barriers.This review mainly discusses the characteristics,transport mechanism and research advances of FcRn. |
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| Keywords: | FcRn IgG transcytosis epithelial barrier |
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