Effect of dietary rosemary extract on cell-mediated immunity of young rats |
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| Authors: | US Babu PL Wiesenfeld MY Jenkins |
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| Institution: | (1) Division of Science and Applied Technology, Offices of Special Nutritionals, US Food and Drug Administration, Laurel, MD 20708, USA;(2) Division of Science and Applied Technology, Offices of Food Labeling, US Food and Drug Administration, Laurel, MD 20708, USA |
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| Abstract: | The impact of rosemary extract on splenic mononuclear cell proliferation was determined. Weanling male Sprague-Dawley rats were fed diets containing 0, 100, 200 or 400 ppm rosemary extract or 400 ppm butylated hydroxytoluene (BHT) in combinatiion with 10 or 20% casein enriched diets for 8 weeks. Splenic mononuclear cells were isolated from these animals and mitogenic response to Concanavalin A (Con A), Phytohemagglutinin (PHA) and lipopolysaccharide was determined. Con A and PHA-stimulated proliferation of spleen cells from rats fed 10% casein and 200 ppm rosemary extract was significantly higher than that of cells from the corresponding control animals. However, other levels of rosemary at 10% dietary casein or rosemary at any concentration fed along with 20% dietary casein had no impact on the mitogenic stimulation of splenic mononuclear cells. Thus, these results suggest that the use of rosemary might not have a generalized immunoenhancing effect, and will probably be effective in some stressed conditions, such as protein or antioxidant deficiency. |
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| Keywords: | Concanavalin A Mitogenic response Phytohemagglutinin Rosemary extract Splenic lymphocytes Stabex |
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