The pharmacokinetics of dihydrostreptomycin sulfate in domestic pigeons (Columba livia Gmel., 1789 var. domestica)] |
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| Authors: | O F Mutlu |
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| Institution: | Institut für Geflügelkrankheiten, Ludwig-Maximilians-Universit?t München. |
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| Abstract: | A 20% aqueous solution of dihydrostreptomycin sulfate in a dosage of 100 mg/kg b.w. is non-toxic for pigeons, although renal accumulation occurs. 12 hours after a single subcutaneous injection of 100 mg/kg b.w. the plasma concentration decreases to 3.64 micrograms/ml and therefore below the therapeutically effective concentration, while in birds suffering from salmonella infections plasma levels decrease to comparative concentrations (3.84 micrograms/ml) after only 8 hours. Contrary to the directions for use in pigeons of the preparation CX 60, the subsequent dosage should be given no later than 10 hours after the first application. |
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