| 党参多糖对D-半乳糖衰老模型小鼠的影响 |
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| 引用本文： | 郭晓农,;王兵,;张念姣,;王岳,;戚欢阳.党参多糖对D-半乳糖衰老模型小鼠的影响[J].中兽医医药杂志,2014(3):45-47. |
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| 作者姓名： | 郭晓农 ;王兵 ;张念姣 ;王岳 ;戚欢阳 |
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| 作者单位： | [1]西北民族大学生命科学与工程学院,甘肃兰州730030; [2]中国科学院近代物理研究所,甘肃兰州730000; [3]中国科学院兰州化学物理研究所甘肃省天然药物重点实验室,甘肃兰州730000 |
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| 基金项目： | 中央高校基本科研业务费专项资金资助（zyz2011071）; 西北民族大学中青年科研项目（XBMU-2010-BD-125）; 西北民族大学本科教学建设项目12JG-1606632 |
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| 摘 要： | 目的：研究党参多糖（CPPS）的抗衰老作用。方法：选用D-半乳糖（D-gal）诱导建立小鼠衰老模型,CPPS分别按250 mg/kg、150 mg/kg、50 mg/kg连续灌胃,观察CPPS对小鼠肝脏组织MDA含量的影响。结果：CPPS可以显著降低小鼠肝脏组织MDA含量（P〈0.01）,减轻D-gal对小鼠肝细胞的毒性。结论：CPPS对D-gal所致衰老小鼠的肝组织毒性具有显著的保护作用,这种保护效应可能与CPPS抗氧化的作用机制有关。
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| 关 键 词： | 党参多糖 抗氧化 抗衰老 丙二醛 肝损伤 |
Effects of polysaccharide from Codonopsis pilosula on D-galactose induced model of aging mice |
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| Institution: | GUO Xiao-nong, WANG Bing, ZHANG NIAN-Jiao, WANG Yue, QI Huan-yang ( 1 .College of Life Science and Engineering, Northwest University for Nationalities, Lanzhou Gansu 730030; 2.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou Gansu 730000; 3.Key Laboratory of Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou Gansu 730000, China) |
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| Abstract: | Objective： To study the anti-aging effect of Codonopsis pilosula polysaccharide（CPPS） in mice. Methods：CPPS was intragastric administrated to aging model mice induce by injection of D-galactose at the dosage of 250 mg/kg,150 mg/kg and 50 mg/kg, respectively, then malondialdehyde（MDA） content in liver were measured. Results： CPPS could significantly decrease（P0.01） the contents of MDA in liver and reduced the toxic effect of D-gal on liver cells. Conclusion：CPPS has protective effect on D-gal induced hepatic injury in aging model mice by enhancing antioxidant defenses. |
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| Keywords: | Codonopsis pilosula polysaccharide antioxidant anti-aging MDA hepatic injury |
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