| 西藏茎直黄芪对山羊的毒性研究 |
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| 引用本文： | 赵宝玉,鲁西科.西藏茎直黄芪对山羊的毒性研究[J].畜牧兽医学报,1992,23(3):276-280. |
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| 作者姓名： | 赵宝玉 鲁西科 |
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| 作者单位： | 西北农业大学兽医系
(赵宝玉，曹光荣，段得贤，李绍君)，西藏自治区畜牧局
(鲁西科)，西藏自治区畜牧局(王俊彪) |
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| 摘 要： | 本试验经瘤胃瘘管每天给6只山羊投股茎直黄芪粉(20g/kgB·W),并且给每只山羊茎直黄芪干草(200g/day),令其自由采食。第40～47天受试山羊出现以中枢神经系统机能紊乱为特征的中毒症状,表现为精神沉郁,摇头,目光呆滞,反应迟钝,步态蹒珊。继之,后肢无力,后躯麻痹,卧地不起。实验室检查发现,中毒羊血清AKP、GOT活性和BUN含量明显升高。病理组织学变化主要表现为神经细胞广泛空泡化。经分析茎直黄芪含苦马豆素,不含脂肪族硝基化合物,不是聚硒植物,从而证实苦马豆素可能是茎直黄芪的主要有毒成分。
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| 关 键 词： | 茎直黄芪 苦马豆素 山羊 中毒 |
A STUDY ON TOXICITY OF ASTRAGALUS STRICTUS IN GOATS IN TIBET |
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| Zhao Baoyu,Cao Guangrong,Duan Dexian,Li Shaojun.A STUDY ON TOXICITY OF ASTRAGALUS STRICTUS IN GOATS IN TIBET[J].Acta Veterinaria et Zootechnica Sinica,1992,23(3):276-280. |
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| Authors: | Zhao Baoyu Cao Guangrong Duan Dexian Li Shaojun |
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| Abstract: | Certain dosage of pulverized astragalus strictus ( 20g/kgB. W ) isgiven to 6 goats per day via rumen fistula, supplemented with the dried plants ( 200g/day ) for each animal ad libitum. The goats appeared toxic signs characterized by CNS disorders: depression, shaking head, staring eyes, dull, ataxia on the day 40-47 of the experiment; at last hind limbs weakness, hind quarter paralysis, recumbency. Laboratory examination showed serum AKP,GOT and BUN increased significantly. Histopathological examination showed neuro visceral cytoplasma vacu-olation. Analysis of the plant showed that A. strictus, which is not a selenium accumlator and has no aliphatic nitro-toxins, contains indolizidine alkaloidswainsonine. It is considered that swainsonine may be main toxin compound of A. strictus. |
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| Keywords: | Astragalus strictus Swainsonine Locodisease |
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