Flavonoid-induced autophagy in hormone sensitive breast cancer cells |
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| Authors: | Elisa Brunelli Giulia Pinton Paolo Bellini Alberto Minassi Giovanni Appendino Laura Moro |
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| Institution: | aDipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Via Bovio 6, 28100 Novara, Italy |
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| Abstract: | The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity. |
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| Keywords: | 8-Prenylapigenin 8-Prenylnaringenin Isocannflavin B Breast cancer cells Cell signalling Autophagy |
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