| 荷斯坦牛免疫抗病相关Nramp1基因生物信息学分析 |
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| 引用本文： | 张梦帆,李耀东.荷斯坦牛免疫抗病相关Nramp1基因生物信息学分析[J].中国奶牛,2022(2):11-15. |
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| 作者姓名： | 张梦帆 李耀东 |
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| 作者单位： | 西北民族大学生命科学与工程学院 |
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| 基金项目： | 西北民族大学引进人才科研项目(Z15124);西北民族大学中央高校基本科研业务费资金资助项目(31920190202-02,31920180005)。 |
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| 摘 要： | 为研究牛的抗病能力,探究荷斯坦牛Nramp1基因所编码蛋白的结构与功能,本研究采用生物信息学分析的方法对荷斯坦牛Nramp1基因编码蛋白质的理化性质、疏水性/亲水性、信号肽跨膜区、跨膜结构域、N-糖基化位点和磷酸化位点、蛋白质二级结构、三级结构及蛋白质互作进行分析和预测.结果表明,荷斯坦牛Nramp1基因所编码蛋白全长...
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| 关 键 词： | 荷斯坦牛 Nramp1基因 生物信息学 |
Bioinformatics Analysis of NRAMP1 Gene Associated with Immune Resistance in Holstein Cattle |
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| ZHANG Meng-fan,LI Yao-dong.Bioinformatics Analysis of NRAMP1 Gene Associated with Immune Resistance in Holstein Cattle[J].China Dairy Cattle,2022(2):11-15. |
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| Authors: | ZHANG Meng-fan LI Yao-dong |
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| Institution: | (Life Science and Engineering College of Northwest University for Nationalities,Northwest Minzu University,Lanzhou 730030) |
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| Abstract: | The structure and function of protein encoded by NRAMP1 gene in Holstein cattle were studied in order to study the disease resistance of cattle, In this study, we analyzed and predicted the physical and chemical properties,hydrophobicity/hydrophilicity, signal peptide transmembrane domain, transmembrane domain, N-glycosylation site and phosphorylation site, secondary structure, and tertiary structure of protein and protein interaction of the protein encoded by NRAMP1 gene of Holstein cattle by bioinformatics analysis. The results showed that NRAMP1 was an unstable hydrophobic protein with a total length of 548 amino acids and an isoelectric point of 6.39. The secondary structure is mainly composed of α-helix and random coil, with 41 potential phosphorylation sites and 1 N-glycosylation site. And there are related proteins. The results of this study have certain theoretical significance for further study of NRAMP1 gene in Holstein cattle. |
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| Keywords: | Holstein cattle NRAMP1 gene Bioinformatics |
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