| 交感神经阻断小鼠妊娠早期子宫内肥大细胞的分布 |
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| 引用本文： | 董玉兰,陈耀星,王子旭,荆海霞.交感神经阻断小鼠妊娠早期子宫内肥大细胞的分布[J].中国兽医学报,2007,27(1):121-125. |
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| 作者姓名： | 董玉兰 陈耀星 王子旭 荆海霞 |
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| 作者单位： | 中国农业大学,动物医学院,北京,100094 |
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| 摘 要： | 为了研究交感神经对哺乳动物早期胚胎发育的影响机制,通过腹腔注射6-羟多巴胺使交感神经阻断后,观察了小鼠妊娠前期胚胎早期发育和肥大细胞数量和型别的变化。结果显示,交感神经阻断后,不仅对胚胎早期发育有影响,使胚胎着床数降低64.4%,而且影响子宫内肥大细胞的数量及其型别分布。妊娠4d(E4)时肥大细胞数量明显升高(P<0.01),同时肥大细胞分型也有所变化,即黏膜型肥大细胞主要存在于胚胎着床前和着床后,结缔组织型肥大细胞没有明显差异,混合型肥大细胞主要存在于着床期间。这一结果表明,妊娠早期子宫肥大细胞数量与型别的变化可能是交感神经影响早期胚胎发育的途径之一。
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| 关 键 词： | 交感神经 子宫 肥大细胞 妊娠 早期胚胎发育 |
| 文章编号： | 1005-4545(2007)01-0121-05 |
| 修稿时间： | 2005-06-10 |
Distribution of mast cells in early pregnant uterus of sympatholytic mice |
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| DONG Yu-lan,CHEN Yao-xing,WANG Zi-xu,JING Hai-xia.Distribution of mast cells in early pregnant uterus of sympatholytic mice[J].Chinese Journal of Veterinary Science,2007,27(1):121-125. |
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| Authors: | DONG Yu-lan CHEN Yao-xing WANG Zi-xu JING Hai-xia |
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| Institution: | College of Animal Medicine, China Agricultural University, Beijing 100094, China |
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| Abstract: | To investigate effect of sympathetic nerve on early development of embryo,a model of sympatholytic mice was established by 6-OHDA. The results showed that the number of embryo implantation rate decreased by 64.4%,the population of mast cell decreased obviously in the uterus of the sympatholytic mice,and the number of mucosal mast cells(MMC) increased before and after embryo implantation.The number of connective tissue mast cells(CTMC) was similar to that of normal mouse,and the compound mast cell occurred during embryo implantation.The results indicated that changes of population and distribution of mast cell might be one of effects of sympathetic nerve on carly development of embryo. |
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| Keywords: | sympathetic nerve uterus mast cell pregnancy early embryo development |
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