| 茶多酚对机体清除自由基和抗DNA损伤的作用 |
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| 引用本文： | 刘明哲,杨贤强,苏燎原.茶多酚对机体清除自由基和抗DNA损伤的作用[J].浙江大学学报(农业与生命科学版),1992(Z1). |
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| 作者姓名： | 刘明哲 杨贤强 苏燎原 |
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| 作者单位： | 浙江中医学院，浙江农业大学，苏州医学院 杭州 310009，杭州 310029，苏州 215007 |
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| 摘 要： | 通过茶多酚(TP)对青、老年NIH小鼠血清中丙二醛(MDA)、红细胞超氧化物歧化酶(SOD)和过氧化氢酶(CAT)活性的作用研究了它对机体自由基的清除功效,并以人体淋巴细胞DNA单链断裂为指标研究了TP对辐射诱发的DNA损伤的保护作用.结果显示:0.05％TP饮饲15天可明显降低青、老年小鼠血清MDA含量(P<0.01)、提高青、老年小鼠红细胞SOD活性(P<0.05)和老年小鼠CAT活性(P<0.05),但青年鼠CAT活性未见提高.0.1～1.0mg/mL TP处理,可明显降低20 GY ~(50)Coγ-线诱发的人体外周淋巴细胞DNA单链断裂,其中以0.1mg/mL TP处理24小时为最佳.
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| 关 键 词： | 茶多酚 丙二醛 超氧化物歧化酶 过氧化氢酶 DNA单链断裂 |
Effects of tea polyphenols on scavenging free radicals and protecting DNA from damage in organism. |
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| Liu Mingzhe,Yang Xianqiang, Su Liaoyuan.Effects of tea polyphenols on scavenging free radicals and protecting DNA from damage in organism.[J].Journal of Zhejiang University(Agriculture & Life Sciences),1992(Z1). |
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| Authors: | Liu Mingzhe Yang Xianqiang Su Liaoyuan |
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| Abstract: | The effect of tea polyphenols (TP) on.scavenging free radicals and protecting DNA from damage in organism were studied, The results showed that free drinking of 0. 05% TP for 15 days could significantly decrease MDA level in serum of young and old mice and enhance superoxide dismutase (SOD) activity in red blood cells of the young and old mice and catalase (CAT) activity in red blood cells of old mice. The treatment of 0. 1 -1.0 mg/ml TP could remarkably reduce DNA single strand break induced by 20 GY r-ray in human peripheral lymphocytes. Among the 3 TP treatments, the 0. 1 mg/ml TP for 24 hr gave the best protective effect on DNA single strand break. |
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| Keywords: | tea polyphenols MDA SOD CAT DNA single strand break |
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