Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo |
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| Authors: | Zhang-Hua Sun Ying-Hong Cai Cheng-Qi Fan Gui-Hua Tang Hai-Bin Luo Sheng Yin |
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| Institution: | 1.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China; E-Mails: (Z.-H.S.); (Y.-H.C.); (G.-H.T.); (H.-B.L.);2.East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China; E-Mail: |
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| Abstract: | Six new tetraprenylated alkaloids, designated as malonganenones L–Q (1–6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1–6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1–6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 µM, respectively. |
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| Keywords: | gorgonian Echinogorgia pseudossapo tetraprenylated alkaloids phosphodiesterases |
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