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Bis-pyrimidylpyrazolinones – a new class of acetohydroxy-acid synthase (AHAS) inhibitor |
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| Authors: | Stefan Scheiblich Monika Geringer Bodo Kind |
| Abstract: | Hydroxypyrazolinones which bear two pyrimidine rings (on N-1 and C-4) were found to be potent inhibitors of acetohydroxy-acid synthase which displayed good herbicidal activity in vivo. Structure–activity relationship studies suggested the presence of a second binding niche on the enzyme for a 4,6-dimethoxypyrimidine ring. |
| Keywords: | acetohydroxy-acid synthase dimethoxypyrimidine herbicide pyrazolinones structure– activity relationship |