Efficacy of albendazole against nematode parasites isolated from a goat farm in Ethiopia: relationship between dose and efficacy in goats |
| |
| Authors: | Tadesse Eguale Hassen Chaka Daniel Gizaw |
| |
| Institution: | (1) Ministry of Agriculture and Rural Development of Ethiopia, National Animal Health Diagnostic and Investigation Center, P.O. Box 04, Sebeta, Ethiopia |
| |
| Abstract: | A suspected case of albendazole resistance in a goat farm of Hawassa University was examined using faecal egg count reduction
test (FECRT), controlled anthelmintic efficacy test and egg hatch assay (EHA) to verify the development of resistance and/or
the need for higher doses of the drug in goats than in sheep. The experiment was conducted in 12 sheep (2 groups: treatment
versus control) and 24 goats (4 groups: 3 treatments versus control, n = 6; per group) following artificial infection with
infective larvae of Haemonchus contortus and Oesophagostomum columbianum. The first group of sheep and goats were treated orally with albendazole at the dose rate of 3.8 mg/kg body weight (i.e. manufacturer's
recommended dose for sheep) while the second group of sheep and the fourth group of goats were left untreated. The second
and the third group of goats were treated with albendazole at 5.7 and 7.6 mg/kg respectively. The FECRT showed an efficacy
of albendazole in goats to be 65.5, 81.4 and 84.1% at the dose rate of 3.8, 5.7 and 7.6 mg/kg body weight respectively while
in sheep it was 62% at the dose rate of 3.8 mg/kg. Increasing the dose to 1.5 the sheep recommended dose induced minor improvement
of efficacy in goats; however the efficacy was almost the same at 1.5 and twice the dose recommended for sheep. Worm counts
at day 15 post-treatment revealed that H. contortus has developed resistance to albendazole. EHA results also supported these findings. On the other hand, O. columbianum was 100% susceptible at all dose levels tested. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
