Effect of dose and source of supplemental zinc on immune response and oxidative enzymes in lambs |
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| Authors: | D Nagalakshmi K Dhanalakshmi D Himabindu |
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| Institution: | (1) Department of Animal Nutrition, College of Veterinary Science, Sri Venkateswara Veterinary University, Rajendranagar, Hyderabad, 500 030, India;(2) Department of Veterinary Microbiology, College of Veterinary Science, Sri Venkateswara Veterinary University, Rajendranagar, Hyderabad, 500 030, India |
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| Abstract: | An experiment of 150 days was conducted on 42 male Nellore lambs (28.3 ± 0.64 kg) to determine the effect of zinc (Zn) supplementation
(0,15, 30 and 45 ppm) in diet from inorganic (ZnSO4) and organic (Zn proteinate) sources on immune response and antioxidant enzyme activities by allotting them randomly to 7
groups in completely randomized design. The basal diet (BD) contained 29.28 ppm Zn. The humoral immune response assessed at
75 d against B. abortus was higher (P<0.01) with 15 or 30 ppm Zn supplementation from organic source. The dose and source had no effect on titres
against chicken RBC antigen. The cell mediated immune response assessed as delayed type hypersensitivity (DTH) response against
phytohaemagglutinin-P and in vitro lymphocyte proliferative response against concanavalin A at 150 d was higher (P<0.05) at 15 ppm Zn supplementation compared
to BD fed lambs. Supplementation of 45 ppm Zn had no positive effect on immune response. The DTH response and antibody titres
against B.abortus were higher (P< 0.05) on Zn proteinate compared to ZnSO4 at 15 ppm Zn supplementation. The lipid peroxidase activity was lower (P < 0.01), while the RBC superoxide dismutase and
catalase activities were higher (P < 0.01) in lambs at 15 ppm Zn supplementation compared to BD diet fed lambs, assessed at
75 d of feeding. Serum globulin concentration and alkaline phosphatase (ALP) activity (75 d of experiment) was higher in Zn
supplemented lambs. The ALP activity increased (P < 0.01) with increase in Zn supplementation and being higher when supplementation
was from Zn proteinate compared to ZnSO4. The study indicated that 15 ppm zinc supplementation was required for obtaining higher immune response in lambs when fed
a basal diet containing 29.28 ppm Zn and supplementation as Zn proteinate had higher antioxidant enzyme activities and immune
response compared to ZnSO4. |
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