Q fever epidemic in Cayenne,French Guiana,epidemiologically linked to three-toed sloth |
| |
| Institution: | 1. Military Center for Epidemiology and Public health, CESPA, Marseille, France;2. Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France;3. Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France;4. Institut Pasteur, Cayenne, French Guiana, France;5. Andrée Rosemon Hospital, Cayenne, French Guiana, France;6. Direction Interarmées du Service de Santé en Guyane, Cayenne, French Guiana, France;7. French Forces Medical Service Working Group on Animal Epidemiology, DRSSA Toulon, France;8. French Military Health Service Academy – École du Val-de-Grâce, Paris, France;9. Aix-Marseille Université, URMITE, Marseille, France;1. Department of Microbiology, Chung-Ang University, College of Medicine, Seoul, South Korea;2. Central Vietnam Veterinary Institute, Nha Trang, Viet Nam;1. Inmunología y Genética Aplicada, S.A. (INGENASA), C/Hermanos García Noblejas 39, 28037, Madrid, Spain;2. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria – Centro de Investigación en Sanidad Animal (INIA-CISA), Ctra Algete-El Casar s/n, 208130, Valdeolmos, Madrid, Spain;3. Instituto de Investigación en Recursos Cinegéticos (CSIC-UCLM), Ronda de Toledo 12, 13005 Ciudad Real, Spain;4. Estación Biológica de Doñana CSIC, Calle Américo Vespucio, s/n, 41092, Seville, Spain;5. Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública (CIBERESP), Spain;1. Department of Parasitology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;2. Department of Microbiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;3. Department of infectious Diseases, Razi Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;4. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;1. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran;3. Department of Pathobiology, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran;4. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;5. Isfahan Veterinary Offices, Head of Public Health Supervision Section, Isfahan, Iran;1. National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, 11000, Thailand;2. Nongkwang Livestock Breeding and Research Center, 128, Moo 10, Tambol Khaochangum, Photharam District, Ratchaburi, 70120, Thailand;3. Laboratory of Veterinary Public Health, College of Bioresource Sciences, Nihon University Fujisawa, Kanagawa, 252-0880, Japan;4. Rajapruk University, Bangkhanoon, Banggruay, Nonthaburi, 11130, Thailand;5. Faculty of Animal Science and Technology, Maejo University, Nongharn, Sansai District, Chiang Mai, 50290, Thailand |
| |
| Abstract: | A Q fever epidemic occurred in 2013 in a small military residential area in Cayenne, French Guiana. A retrospective cohort study was conducted to identify Q fever risk factors. Confirmed acute Q fever case was defined as positive serology (IgM ≥ 50 and phase II IgG ≥ 200) and/or positive qPCR on serum or blood. In addition, wild mammals were captured at the study site and tested by serology and real-time PCR performed on blood, vaginal swabs and ticks. The attack rate was 20 percent (11/54). All the cases were symptomatic with fever >38.5 °C and community-acquired pneumonia for four cases. Log binomial multivariate models identified two independent risk factors associated with Q fever: to clean the house (RRa = 7.5 CI95% 1.03–55.3]) and to carry a three-toed sloth in arms (RRa = 2.6 CI95% 1.1–5.8]). Eighteen marsupial individuals were captured, all PCRs were negative but 17% (3/18) had a positive serology. Another study conducted after the epidemic found only one (1/4) three-tooth sloth (Bradypus tridactylus) with feces highly infectious for C. burnetii MST17. The same strain C. burnetii genotype 17 has been laboratory- confirmed in this mammal and in human cases. These results support the implication of three-toed-sloth in this epidemic. Human contamination mainly occurs through inhalation of infectious aerosols as suggested by high relative risk associated with house cleaning activities and pulmonary forms of the disease, and through direct contact with three- toed-sloth. Positive serological results among marsupials confirm wildlife exposure and suggest a more complex sylvatic transmission cycle among wild mammals. |
| |
| Keywords: | Q fever Military Outbreak Epidemic French Guiana Epidemiology Sloth |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
