Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection |
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| Authors: | Kawakubo Masatomo Ito Yuki Okimura Yukie Kobayashi Motohiro Sakura Kyoko Kasama Susumu Fukuda Michiko N Fukuda Minoru Katsuyama Tsutomu Nakayama Jun |
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| Institution: | Department of Pathology, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan. |
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| Abstract: | Helicobacter pylori infects the stomachs of nearly a half the human population, yet most infected individuals remain asymptomatic, which suggests that there is a host defense against this bacterium. Because H. pylori is rarely found in deeper portions of the gastric mucosa, where O-glycans are expressed that have terminal alpha1,4-linked N-acetylglucosamine, we tested whether these O-glycans might affect H. pylori growth. Here, we report that these O-glycans have antimicrobial activity against H. pylori, inhibiting its biosynthesis of cholesteryl-alpha-D-glucopyranoside, a major cell wall component. Thus, the unique O-glycans in gastric mucin appeared to function as a natural antibiotic, protecting the host from H. pylori infection. |
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