| 应用分子靶点药物治疗犬肥大细胞瘤的研究进展 |
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| 引用本文： | 李格宾,杨紫嫣,林珈好,夏兆飞.应用分子靶点药物治疗犬肥大细胞瘤的研究进展[J].动物医学进展,2016(2):80-84. |
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| 作者姓名： | 李格宾 杨紫嫣 林珈好 夏兆飞 |
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| 作者单位： | 中国农业大学动物医学院,北京,100193 |
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| 基金项目： | 中央高校基本科研业务费专项资金 |
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| 摘 要： | 犬肥大细胞瘤因其恶性率和转移率都较高,并且常规化疗药物副作用较强,患犬生存期和生存质量显著下降,因此急需新型的药物进行治疗。近几年,治疗肿瘤的分子靶点药物凭借其疗效好、副作用低的特点,受到越来越广泛的关注,特别是在治疗犬肥大细胞瘤的应用中效果显著。论文重点介绍了欧美小动物临床最常用的伊马替尼、托赛拉尼、马赛替尼这3种以异常KIT为靶点的药物及其药物作用机理及药效,最后介绍了由c-kit基因二次突变所导致的耐药问题及其预防措施,期望能对我国小动物临床医师和科研工作者有所启发。
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| 关 键 词： | 犬 肥大细胞瘤 分子靶点药物 c-kit基因 |
Progress on Application of Molecular Target Drugs in Treatments of Canine Mast Cell Tumors |
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| Abstract: | Mast cell tumors (MCT)have the high metastatic and mortality rate.Moreover,the convention-al chemotherapy drugs have many unpleasant side effects.As such,dogs with anaplastic MCT remain a frustrating undertaking of survival time and quality of life.Therefore,it is necessary to have better under-standing of novel,effective drugs for control of MCT.With the dramatically development of molecule biol-ogy in oncology field,molecular target drugs have been aroused general concern because of their great effect and low side-effect.Especially,molecular target drugs have attained remarkably effect of canine MCT treatment.In the present paper,we emphasized the mechanism and effect of three drugs (Imatinib, Toceranib and Masitinib)which are the most commonly used in America and Europe and targeted to the c-kit gene.At last we showed the drug resistance and preventive measure caused by second mutation of c-kit gene.We hope these could provide references to scientific researchers and small animal clinical practitioners in China. |
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| Keywords: | canine mast cell tumor molecular target drug c-kit gene |
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