Catalytic antibodies with lipase activity and R or S substrate selectivity |
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| Authors: | K D Janda S J Benkovic R A Lerner |
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| Institution: | Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037. |
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| Abstract: | The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (10(3) to 10(5] above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis. |
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