The inheritance of chemical phenotype in Cannabis sativa L. (II): Cannabigerol predominant plants |
| |
| Authors: | E P M de Meijer K M Hammond |
| |
| Institution: | (1) GW Pharmaceuticals plc., Porton Down Science Park, Salisbury, Wiltshire, SP4 0JQ, UK |
| |
| Abstract: | This paper aims to clarify the genetic mechanism that is responsible for the accumulation of cannabigerol (CBG) in certain
phenotypes of Cannabis sativa L. CBG is the direct precursor of the cannabinoids CBD, THC and CBC. Plants strongly predominant in CBG have been found in
different fibre hemp accessions. Inbred offspring derived from one such individual were crossed with true breeding THC predominant-
and CBD predominant plants, respectively. The segregations in the cross progenies indicate that CBG accumulation is due to
the homozygous presence of a minimally functional allele, tentatively called B0, at the single locus B that normally controls the conversion of CBG into THC (allele BT) and/or CBD (allele BD). The fact that CBG accumulating plants have so far been found in European fibre hemp populations that are generally composed
of BD/BD plants, and the observation that the here investigated B0 allele possesses a residual ability to convert small amounts of CBG into CBD, make it plausible that this B0 is a mutation of normally functional BD. Therefore, B0 is considered as a member of the BD allelic series encoding a CBD synthase isoform with greatly weakened substrate affinity and/or catalytic capacity. |
| |
| Keywords: | cannabigerol cannabinoids Cannabis chemotype inheritance |
| 本文献已被 SpringerLink 等数据库收录！ |
|
